In previous works, Vandermonde-subspace frequency division multiplexing (VFDM) has been shown to promote overlay networks by enabling a secondary transmitter to cancel its interference to a primary receiver, while simultaneously transmitting useful information to its own receiver at nonnegligible rates. Interference cancelation is achieved by exploiting the null-space of the channel from the secondary transmitter to the primary receiver. In the wake of a global deployment of the third generation partnership project’s (3GPP) long term evolution (LTE), one of the open questions of VFDM concerns its applicability in a primary LTE-orthogonal frequency division multiple access (OFDMA) multi-user setting. In this work, we address this question by extending VFDM to the multi-user scenario where the primary system employs OFDMA, such as LTE. We show that by using at the secondary system a similar precoder structure to the ones previously studied, we are able to cancel the interference towards multiple primary receivers while still achieving acceptable rates for the secondary system.